Cosmeceutics company uses Malvern Zetasizer Nano to characterise environmentally responsive nanoparticles
The rapid, real-time measurement capabilities of the Zetasizer Nano system from Malvern Instruments have enabled quantified nanoscale characteridation of the environmental sensitivity of novel solubilidation nanoparticles. A joint research paper, presented at Particulate Systems Analysis 2008 and a new publication in Cosmetics & Toiletries Sep 2010 illustrate the application of dynamic light scattering (DLS) to investigate the effects of pH and temperature on the structure and particle size of environmentally-responsive Lipodisq® systems produced by Malvern Cosmeceutics, UK.
Lipodisqs are designed to mimic naturally occurring high-density lipoproteins which bind cholesterol for transport back to the liver for excretion. Composed of a phospholipid membrane core bound together into spherical or disc-like structures by a responsive chaperone molecule (a protein that assists non-covalent folding/unfolding), these particles can enclose and transport oil soluble molecules through an aqueous environment. Used to improve topical delivery of an active botanic or pharmaceutical ingredient, Lipodisqs can be engineered to withstand or respond to particular environmental specifications.
Using the Zetasizer Nano it was demonstrated that Poly(styrene-maleic acid) Lipodisq particles are sensitive to changes in pH, increasing in particle size from ~12nm to >200 nm over a pH range of 7.7 to 5.7. The temperature sensitivity of Poly(styrene-maleic acid) Lipodisq particles was also shown with an increase in parti sly reassemble when these environmental changes were reversed.
Dynamic light scattering (DLS) is a particle sizing technique that delivers rapid, real-time data that are sensitive enough to demonstrate subtle changes over time for sizes below 1 nm. As such it is particularly suited to the investigation of environmentally triggered particle size changes in topical applications such as creams, gels and lotions. www.malvern.com/zetasizer
For more information, contact:
Soloni Gosalia Malvern Aimil Instruments Pvt. Ltd. Naimex House, BSEL Tech Park B Wing – 906 Sector 30A Opp Vashi Railway Station, Vashi, Navi Mumbai 400 705, India Tel: + 91 22 3918 3596: Fax: +91 22 3918 3562